Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury | Zendy

Erwin A. van Vliet | Zendy; Xavier Ekolle NdodeEkane | Zendy; Lauri J. Lehto | Zendy; Jan A. Gorter | Zendy; Pedro Andrade | Zendy; Eleonora Aronica | Zendy; Olli Gröhn | Zendy; Asla Pitkänen | Zendy

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Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury

Author(s) -

Erwin A. van Vliet,

Xavier Ekolle NdodeEkane,

Lauri J. Lehto,

Jan A. Gorter,

Pedro Andrade,

Eleonora Aronica,

Olli Gröhn,

Asla Pitkänen

Publication year - 2020

Publication title -

neurobiology of disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.205

H-Index - 166

eISSN - 1095-953X

pISSN - 0969-9961

DOI - 10.1016/j.nbd.2020.105080

Subject(s) - traumatic brain injury , medicine , extravasation , neuroinflammation , blood–brain barrier , anesthesia , magnetic resonance imaging , pathology , status epilepticus , epilepsy , inflammation , central nervous system , radiology , psychiatry

Rats and humans with TBI have long-lasting cortical BBB dysfunction and neuroinflammation. Focal Gd-enhancement matched with loci of neuroinflammation, particularly in the thalamus. Although BBB leakage did not associate with increased seizure susceptibility after TBI, our data suggest that treatments aimed to mitigate BBB damage and its secondary pathologies like chronic neuroinflammation, have a region-specific long-lasting therapeutic time window.

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