Neuroimaging in genetic frontotemporal dementia and amyotrophic lateral sclerosis | Zendy

Suvi Häkkinen | Zendy; Stephanie A. Chu | Zendy; Suzee E. Lee | Zendy

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Neuroimaging in genetic frontotemporal dementia and amyotrophic lateral sclerosis

Author(s) -

Suvi Häkkinen,

Stephanie A. Chu,

Suzee E. Lee

Publication year - 2020

Publication title -

neurobiology of disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.205

H-Index - 166

eISSN - 1095-953X

pISSN - 0969-9961

DOI - 10.1016/j.nbd.2020.105063

Subject(s) - c9orf72 , frontotemporal dementia , amyotrophic lateral sclerosis , tardbp , neuroimaging , neuroscience , sod1 , psychology , dementia , medicine , pathology , disease

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) have a strong clinical, genetic and pathological overlap. This review focuses on the current understanding of structural, functional and molecular neuroimaging signatures of genetic FTD and ALS. We overview quantitative neuroimaging studies on the most common genes associated with FTD (MAPT, GRN), ALS (SOD1), and both (C9orf72), and summarize visual observations of images reported in the rarer genes (CHMP2B, TARDBP, FUS, OPTN, VCP, UBQLN2, SQSTM1, TREM2, CHCHD10, TBK1).

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