Dopamine D1-D2 receptor heteromer expression in key brain regions of rat and higher species: Upregulation in rat striatum after cocaine administration | Zendy

Ahmed Hasbi | Zendy; Meenalochani Sivasubramanian | Zendy; Marija Milenković | Zendy; Kristina Komarek | Zendy; Bertha K. Madras | Zendy; Susan R. George | Zendy

Open Access

Dopamine D1-D2 receptor heteromer expression in key brain regions of rat and higher species: Upregulation in rat striatum after cocaine administration

Author(s) -

Ahmed Hasbi,

Meenalochani Sivasubramanian,

Marija Milenković,

Kristina Komarek,

Bertha K. Madras,

Susan R. George

Publication year - 2020

Publication title -

neurobiology of disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.205

H-Index - 166

eISSN - 1095-953X

pISSN - 0969-9961

DOI - 10.1016/j.nbd.2020.105017

Subject(s) - striatum , nucleus accumbens , neuroscience , dopamine , dopamine receptor d2 , ventral tegmental area , colocalization , dopamine receptor d1 , chemistry , dopaminergic , biology

The dopamine D1-D2 heteromer is expressed in key brain cortical and subcortical regions of all species examined. Species differences in striatum revealed greater abundance in human>nonhuman-primate>rat>mouse, suggesting an evolutionary biologic role for the D1-D2 heteromer in higher CNS function. Its upregulation in rat striatum following cocaine points to regulatory significance with possible relevance for clinical disorders such as drug addiction. The dopamine D1-D2 receptor heteromer may represent a potential target for neuropsychiatric and neurodegenerative disorders, given its distribution in highly relevant brain regions.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research