Characterization of a new molecule capable of inhibiting several steps of the amyloid cascade in Alzheimer's disease | Zendy

Christian Peters | Zendy; Denisse Bascuñán | Zendy; Carlos F. Burgos | Zendy; Catalina Bobadilla | Zendy; Juliana González-Sanmiguel | Zendy; Subramanian Boopathi | Zendy; Nicolás Riffo | Zendy; Eduardo J. Fernández-Pérez | Zendy; María Elena Tarnok | Zendy; Luis F. Aguilar | Zendy; Wendy González | Zendy; Luis G. Aguayo | Zendy

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Characterization of a new molecule capable of inhibiting several steps of the amyloid cascade in Alzheimer's disease

Author(s) -

Christian Peters,

Denisse Bascuñán,

Carlos F. Burgos,

Catalina Bobadilla,

Juliana González-Sanmiguel,

Subramanian Boopathi,

Nicolás Riffo,

Eduardo J. Fernández-Pérez,

María Elena Tarnok,

Luis F. Aguilar,

Wendy González,

Luis G. Aguayo

Publication year - 2020

Publication title -

neurobiology of disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.205

H-Index - 166

eISSN - 1095-953X

pISSN - 0969-9961

DOI - 10.1016/j.nbd.2020.104938

Subject(s) - neuroprotection , in silico , in vivo , neurotoxicity , pharmacology , in vitro , amyloid (mycology) , dentate gyrus , peptide , chemistry , neuroscience , hippocampus , toxicity , biology , biochemistry , inorganic chemistry , microbiology and biotechnology , organic chemistry , gene

Currently, there is no effective treatment for AD and the expectations to develop an effective therapy are low. Using in silico, in vitro, and in vivo experiments, we identified a new compound that is able to inhibit Aβ-induced neurotoxicity, specifically aggregation, association to neurons, synaptic toxicity, calcium dyshomeostasis and memory impairment induced by Aβ. Because Aβ toxicity is central to AD progression, the inhibition mediated by this new molecule might be useful as a therapeutic tool.

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