Longitudinal degeneration of the basal forebrain predicts subsequent dementia in Parkinson's disease | Zendy

Joana B. Pereira | Zendy; Sara Hall | Zendy; Mattis Jalakas | Zendy; Michel J. Grothe | Zendy; Olof Strandberg | Zendy; Erik Stomrud | Zendy; Eric Westman | Zendy; Danielle van Westen | Zendy; Oskar Hansson | Zendy

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Longitudinal degeneration of the basal forebrain predicts subsequent dementia in Parkinson's disease

Author(s) -

Joana B. Pereira,

Sara Hall,

Mattis Jalakas,

Michel J. Grothe,

Olof Strandberg,

Erik Stomrud,

Eric Westman,

Danielle van Westen,

Oskar Hansson

Publication year - 2020

Publication title -

neurobiology of disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.205

H-Index - 166

eISSN - 1095-953X

pISSN - 0969-9961

DOI - 10.1016/j.nbd.2020.104831

Subject(s) - basal forebrain , degeneration (medical) , parkinson's disease , neuroscience , dementia , basal ganglia , disease , psychology , basal (medicine) , forebrain , medicine , central nervous system , pathology , insulin

Atrophy of Ch4 precedes and predicts future dementia in PD and is followed by changes in Ch1/Ch2, reflecting a posterior-anterior pattern of basal forebrain atrophy. This pattern could be used to track the spread of cholinergic degeneration and identify patients at risk of developing dementia.

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