Pathological remodelling of colonic wall following dopaminergic nigrostriatal neurodegeneration | Zendy

Carolina Pellegrini | Zendy; Chiara Ippolito | Zendy; Cristina Segnani | Zendy; Amelio Dolfi | Zendy; Mariella Errede | Zendy; Daniela Virgintino | Zendy; Matteo Fornai | Zendy; Luca Antonioli | Zendy; Francesca Garelli | Zendy; Anericcio | Zendy; Rocchina Colucci | Zendy; Silvia Cerri | Zendy; Fabio Blandini | Zendy; Corrado Blandizzi | Zendy; Nunzia Bernardini | Zendy

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Pathological remodelling of colonic wall following dopaminergic nigrostriatal neurodegeneration

Author(s) -

Carolina Pellegrini,

Chiara Ippolito,

Cristina Segnani,

Amelio Dolfi,

Mariella Errede,

Daniela Virgintino,

Matteo Fornai,

Luca Antonioli,

Francesca Garelli,

Anericcio,

Rocchina Colucci,

Silvia Cerri,

Fabio Blandini,

Corrado Blandizzi,

Nunzia Bernardini

Publication year - 2020

Publication title -

neurobiology of disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.205

H-Index - 166

eISSN - 1095-953X

pISSN - 0969-9961

DOI - 10.1016/j.nbd.2020.104821

Subject(s) - pathology , interstitial cell of cajal , biology , immunohistochemistry , medicine

A pathological remodelling occurs in the colon of 6-OHDA rats. The main changes include: enhanced fibrotic deposition; alterations of the epithelial barrier; activation of mucosal defense; reduction of ICCs. These results indicate that central nigrostriatal denervation is associated with histological changes in the large bowel at mucosal, submucosal and muscular level. These alterations might represent morphological correlates of digestive symptoms in PD.

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