Neuronally expressed anti-tau scFv prevents tauopathy-induced phenotypes in Drosophila models | Zendy

Senthilkumar Krishnaswamy | Zendy; Huai-Wei Huang | Zendy; Isabella S. Marchal | Zendy; Hyung Don Ryoo | Zendy; Einar M. Sigurdsson | Zendy

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Neuronally expressed anti-tau scFv prevents tauopathy-induced phenotypes in Drosophila models

Author(s) -

Senthilkumar Krishnaswamy,

Huai-Wei Huang,

Isabella S. Marchal,

Hyung Don Ryoo,

Einar M. Sigurdsson

Publication year - 2020

Publication title -

neurobiology of disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.205

H-Index - 166

eISSN - 1095-953X

pISSN - 0969-9961

DOI - 10.1016/j.nbd.2020.104770

Subject(s) - tauopathy , drosophila (subgenus) , phenotype , neuroscience , microbiology and biotechnology , biology , genetics , neurodegeneration , gene , medicine , disease

We have derived single-chain variable fragments (scFv) from tau antibody hybridomas and previously shown their promise as imaging diagnostic agents. Here, we examined the therapeutic potential of anti-tau scFv in transgenic Drosophila models that express in neurons wild-type (WT) human tau (htau) or the human tauopathy mutation R406W. scFv expressing flies were crossed with the tauopathy flies and analyzed. Overall, the survival curves differed significantly (p In summary, these findings support the therapeutic potential of an anti-tau scFv, including as gene therapies, and the use of Drosophila models for such screening.

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