Four-month treadmill exercise prevents the decline in spatial learning and memory abilities and the loss of spinophilin-immunoreactive puncta in the hippocampus of APP/PS1 transgenic mice | Zendy

Lei Zhang | Zendy; Wei Tang | Zendy; Fenglei Chao | Zendy; Chunni Zhou | Zendy; Lin Jiang | Zendy; Yi Zhang | Zendy; Xin Liang | Zendy; Jing Tang | Zendy; Ying-qiang Qi | Zendy; Hao Yang | Zendy; Qi He | Zendy; Shanshan Zhang | Zendy; Lin Zhu | Zendy; Yan Peng | Zendy; Yong Tang | Zendy

Open Access

Four-month treadmill exercise prevents the decline in spatial learning and memory abilities and the loss of spinophilin-immunoreactive puncta in the hippocampus of APP/PS1 transgenic mice

Author(s) -

Lei Zhang,

Wei Tang,

Fenglei Chao,

Chunni Zhou,

Lin Jiang,

Yi Zhang,

Xin Liang,

Jing Tang,

Ying-qiang Qi,

Hao Yang,

Qi He,

Shanshan Zhang,

Lin Zhu,

Yan Peng,

Yong Tang

Publication year - 2019

Publication title -

neurobiology of disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.205

H-Index - 166

eISSN - 1095-953X

pISSN - 0969-9961

DOI - 10.1016/j.nbd.2019.104723

Subject(s) - hippocampus , dentate gyrus , morris water navigation task , hippocampal formation , treadmill , genetically modified mouse , environmental enrichment , medicine , endocrinology , neuroscience , psychology , transgene , biology , biochemistry , gene

Four-month treadmill exercise induced a significant improvement in spatial learning and memory abilities and a significant increase in the number of spinophilin-immunoreactive puncta of the CA1, CA2-3 and DG in the hippocampus of APP/PS1 mice. Running-induced improvements in spatial learning and memory abilities were significantly correlated with running-induced increases in the spinophilin-immunoreactive puncta numbers in the CA1 and DG of the hippocampus.

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