FAAH inhibition as a preventive treatment for migraine: A pre-clinical study | Zendy

Rosaria Greco | Zendy; Chiara Demartini | Zendy; Anna Maria Zanaboni | Zendy; Elena Tumelero | Zendy; Angelo Reggiani | Zendy; Alessandra Misto | Zendy; Daniele Piomelli | Zendy; Cristina Tassorelli | Zendy

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FAAH inhibition as a preventive treatment for migraine: A pre-clinical study

Author(s) -

Rosaria Greco,

Chiara Demartini,

Anna Maria Zanaboni,

Elena Tumelero,

Angelo Reggiani,

Alessandra Misto,

Daniele Piomelli,

Cristina Tassorelli

Publication year - 2019

Publication title -

neurobiology of disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.205

H-Index - 166

eISSN - 1095-953X

pISSN - 0969-9961

DOI - 10.1016/j.nbd.2019.104624

Subject(s) - anandamide , fatty acid amide hydrolase , pharmacology , hyperalgesia , endocannabinoid system , chemistry , locus coeruleus , central nervous system , medicine , nociception , biochemistry , cannabinoid receptor , receptor , agonist

The findings suggest that global FAAH inhibition may offer a therapeutic approach to the prevention, but not the treatment, of migraine attacks. Further studies are needed to elucidate the exact cellular and molecular mechanisms underlying the protective effects of FAAH inhibition.

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