Gene expression profiling and DNA methylation analyses of CTCs | Zendy

Lianidou Evi S. | Zendy

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Gene expression profiling and DNA methylation analyses of CTCs

Author(s) -

Lianidou Evi S.

Publication year - 2016

Publication title -

molecular oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.332

H-Index - 88

eISSN - 1878-0261

pISSN - 1574-7891

DOI - 10.1016/j.molonc.2016.01.011

Subject(s) - dna methylation , biology , methylation , gene , dna , genomic dna , microbiology and biotechnology , nucleic acid , gene expression , computational biology , genetics

A variety of molecular assays have been developed for CTCs detection and molecular characterization. Molecular assays are based on the nucleic acid analysis in CTCs and are based on total RNA isolation and subsequent mRNA quantification of specific genes, or isolation of genomic DNA that can be for DNA methylation studies and mutation analysis. This review is mainly focused on gene expression and methylation studies in CTCs in various types of cancer.

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