Open AccessGene expression profiling and DNA methylation analyses of CTCs
Author(s) -
Lianidou Evi S.
Publication year - 2016
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1016/j.molonc.2016.01.011
Subject(s) - dna methylation , biology , methylation , gene , dna , nucleic acid , microbiology and biotechnology , genomic dna , illumina methylation assay , gene expression , computational biology , genetics
A variety of molecular assays have been developed for CTCs detection and molecular characterization. Molecular assays are based on the nucleic acid analysis in CTCs and are based on total RNA isolation and subsequent mRNA quantification of specific genes, or isolation of genomic DNA that can be for DNA methylation studies and mutation analysis. This review is mainly focused on gene expression and methylation studies in CTCs in various types of cancer.