Open AccessSenescent stroma promotes prostate cancer progression: The role of miR‐210
Author(s) -
Taddei Maria Letizia,
Cavallini Lorenzo,
Comito Giuseppina,
Giani Elisa,
Folini Marco,
Marini Alberto,
Gandellini Paolo,
Morandi Andrea,
Pintus Gianfranco,
Raspollini Maria Rosaria,
Zaffaroni Nadia,
Chiarugi Paola
Publication year - 2014
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1016/j.molonc.2014.07.009
Subject(s) - angiogenesis , prostate cancer , cancer research , cancer cell , cancer associated fibroblasts , epithelial–mesenchymal transition , biology , stroma , cancer , tumor progression , stromal cell , mesenchymal stem cell , microbiology and biotechnology , immunology , metastasis , immunohistochemistry , genetics
We focused our interest on senescent human‐derived fibroblasts in the progression of prostate cancer. Hypoxic senescent fibroblasts promote prostate cancer aggressiveness by inducing epithelial to mesenchymal transition (EMT) and by secreting energy‐rich compounds to support cancer cell growth. Hypoxic senescent fibroblasts additionally increase: i) the recruitment of monocytes and their M2‐macrophage polarization, ii) the recruitment of bone marrow‐derived endothelial precursor cells, facilitating their vasculogenic ability and iii) capillary morphogenesis, proliferation and invasion of human mature endothelial cells. In addition, we highlight that overexpression of the hypoxia‐induced miR‐210 in young fibroblasts increases their senescence‐associated features and converts them into cancer associated fibroblast (CAF)‐like cells, able to promote cancer cells EMT, to support angiogenesis and to recruit endothelial precursor cells and monocytes/macrophages.