Open AccessIntegrative genomic and transcriptomic characterization of papillary carcinomas of the breast
Author(s) -
Piscuoglio Salvatore,
Ng Charlotte K.Y.,
Martelotto Luciano G.,
Eberle Carey A.,
Cowell Catherine F.,
Natrajan Rachael,
Bidard François-Clement,
De Mattos-Arruda Leticia,
Wilkerson Paul M.,
Mariani Odette,
Vincent-Salomon Anne,
Weigelt Britta,
Reis-Filho Jorge S.
Publication year - 2014
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1016/j.molonc.2014.06.011
Subject(s) - transcriptome , gene expression profiling , biology , breast cancer , cancer research , fusion gene , estrogen receptor , microarray , gene , gene expression , pathology , cancer , medicine , genetics
Papillary carcinoma (PC) is a rare type of breast cancer, which comprises three histologic subtypes: encapsulated PC (EPC), solid PC (SPC) and invasive PC (IPC). Microarray‐based gene expression and Affymetrix SNP 6.0 gene copy number profiling, and RNA‐sequencing revealed that PCs are luminal breast cancers that display transcriptomic profiles distinct from those of grade‐ and estrogen receptor (ER)‐matched invasive ductal carcinomas of no special type (IDC‐NSTs), and that the papillary histologic pattern is unlikely to be underpinned by a highly recurrent expressed fusion gene or a highly recurrent expressed mutation. Despite displaying similar patterns of gene copy number alterations, significant differences in the transcriptomic profiles of EPCs, SPCs and IPCs were found, and may account for their different histologic features.