Open AccessDrug resistance to targeted therapies: Déjà vu all over again
Author(s) -
Groenendijk Floris H.,
Bernards René
Publication year - 2014
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1016/j.molonc.2014.05.004
Subject(s) - targeted therapy , drug resistance , medicine , cancer , acquired resistance , mechanism (biology) , breast cancer , drug , disease , bioinformatics , pharmacology , biology , genetics , philosophy , epistemology
A major limitation of targeted anticancer therapies is intrinsic or acquired resistance. This review emphasizes similarities in the mechanisms of resistance to endocrine therapies in breast cancer and those seen with the new generation of targeted cancer therapeutics. Resistance to single‐agent cancer therapeutics is frequently the result of reactivation of the signaling pathway, indicating that a major limitation of targeted agents lies in their inability to fully block the cancer‐relevant signaling pathway. The development of mechanism‐based combinations of targeted therapies together with non‐invasive molecular disease monitoring is a logical way forward to delay and ultimately overcome drug resistance development.