Open AccessHow animal models of leukaemias have already benefited patients
Author(s) -
Ablain Julien,
Nasr Rihab,
Zhu Jun,
Bazarbachi Ali,
Lallemand-Breittenbach Valérie,
de Thé Hugues
Publication year - 2013
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1016/j.molonc.2013.01.006
Subject(s) - disease , clinical trial , plea , simplicity , biology , cancer , medicine , bioinformatics , computational biology , genetics , pathology , philosophy , epistemology , political science , law
The relative genetic simplicity of leukaemias, the development of which likely relies on a limited number of initiating events has made them ideal for disease modelling, particularly in the mouse. Animal models provide incomparable insights into the mechanisms of leukaemia development and allow exploration of the molecular pillars of disease maintenance, an aspect often biased in cell lines or ex vivo systems. Several of these models, which faithfully recapitulate the characteristics of the human disease, have been used for pre‐clinical purposes and have been instrumental in predicting therapy response in patients. We plea for a wider use of genetically defined animal models in the design of clinical trials, with a particular focus on reassessment of existing cancer or non‐cancer drugs, alone or in combination.