Open Accessp53: Guardian of ploidy
Author(s) -
Aylon Yael,
Oren Moshe
Publication year - 2011
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1016/j.molonc.2011.07.007
Subject(s) - aneuploidy , biology , ploidy , suppressor , cancer research , malignant transformation , neoplastic transformation , cell cycle , cell cycle checkpoint , cancer , chromosome instability , genetics , microbiology and biotechnology , carcinogenesis , gene , chromosome
Aneuploidy, often preceded by tetraploidy, is one of the hallmarks of solid tumors. Indeed, both aneuploidy and tetraploidy are oncogenic occurrences that are sufficient to drive neoplastic transformation and cancer progression. True to form, the tumor suppressor p53 obstructs propagation of these dangerous chromosomal events by either instigating irreversible cell cycle arrest or apoptosis. The tumor suppressor Lats2, along with other tumor inhibitory proteins such as BRCA1/2 and BubR1, are central to p53‐dependent elimination of tetraploid cells. Not surprisingly, these proteins are frequently inactivated or downregulated in tumors, synergizing with p53 inactivation to establish an atmosphere of “tolerance” for a non‐diploid state.