Open AccessThe dual role of the X‐linked FoxP3 gene in human cancers
Author(s) -
Redpath Margaret,
Xu Bin,
van Kempen Leon C.,
Spatz Alan
Publication year - 2011
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1016/j.molonc.2011.03.001
Subject(s) - foxp3 , cancer research , melanoma , suppressor , transcription factor , gene , biology , function (biology) , skin cancer , tumor suppressor gene , cancer , genetics , carcinogenesis , immune system
The FoxP3 (forkhead box P3) gene is an X‐linked gene that is submitted to inactivation. It is an essential transcription factor in CD4+CD25+FoxP3 regulatory T cells, which are therapeutic targets in disseminated cutaneous melanoma. Moreover, FoxP3 is an important tumor suppressor gene in carcinomas and has putative cancer suppressor gene function in cutaneous melanoma as well. Therefore understanding the structure and function of the FoxP3 gene is crucial to gaining insight into the biology of melanoma to better develop immunotherapeutics and future therapeutic strategies.