Open AccessMALDI Imaging Mass Spectrometry – Painting Molecular Pictures
Author(s) -
Schwamborn Kristina,
Caprioli Richard M.
Publication year - 2010
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1016/j.molonc.2010.09.002
Subject(s) - mass spectrometry imaging , maldi imaging , mass spectrometry , analyte , molecular imaging , computational biology , proteomics , chemistry , medicine , chromatography , biology , matrix assisted laser desorption/ionization , biochemistry , microbiology and biotechnology , organic chemistry , adsorption , desorption , in vivo , gene
MALDI Imaging Mass Spectrometry is a molecular analytical technology capable of simultaneously measuring multiple analytes directly from intact tissue sections. Histological features within the sample can be correlated with molecular species without the need for target‐specific reagents such as antibodies. Several studies have demonstrated the strength of the technology for uncovering new markers that correlate with disease severity as well as prognosis and therapeutic response. This review describes technological aspects of imaging mass spectrometry together with applications in cancer research.