Open AccessPrimitive origins of prostate cancer: In vivo evidence for prostate‐regenerating cells and prostate cancer‐initiating cells
Author(s) -
Goldstein Andrew S.,
Stoyanova Tanya,
Witte Owen N.
Publication year - 2010
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1016/j.molonc.2010.06.009
Subject(s) - prostate cancer , prostate , stem cell , cancer stem cell , cancer , biology , cancer cell , cancer research , pathology , medicine , microbiology and biotechnology
Tissue stem cells have been linked to cancers of epithelial origin including the prostate. There are three relevant issues concerning stem cells and cancer that rely solely on functional studies: 1. Are there tissue‐regenerating stem cells in the adult organ? 2. Can tissue‐regenerating cells serve as targets for transformation? 3. Do primary tumors contain tumor‐propagating (cancer stem) cells? We will review the recent literature with respect to these critical issues to provide a direct link between primitive cells and prostate cancer.