Open AccessMicro‐RNAs and breast cancer
Author(s) -
Le Quesne John,
Caldas Carlos
Publication year - 2010
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1016/j.molonc.2010.04.009
Subject(s) - microrna , breast cancer , rna , biology , gene , computational biology , non coding rna , translation (biology) , long non coding rna , cancer , gene expression , messenger rna , cancer research , genetics , microbiology and biotechnology , bioinformatics
Micro‐RNAs (miRs) are a recently described class of genes, encoding small non‐coding RNA molecules, which primarily act by down‐regulating the translation of target mRNAs. miRs are involved in a range of normal physiological processes, notably differentiation and cell type determination. It has become apparent that they are also key factors in cancer, playing both oncogenic and tumour‐suppressing roles. We discuss here what is known of miR biology in the normal breast, and of their emerging roles in breast cancer.