Open AccessEndocytosis and spatial restriction of cell signaling
Author(s) -
Disanza Andrea,
Frittoli Emanuela,
Palamidessi Andrea,
Scita Giorgio
Publication year - 2009
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1016/j.molonc.2009.05.008
Subject(s) - endocytosis , microbiology and biotechnology , biology , cell , computational biology , genetics
Endocytosis and recycling are essential components of the wiring enabling cells to perceive extracellular signals and transduce them in a temporally and spatially controlled fashion, directly influencing not only the duration and intensity of the signaling output, but also their correct location. Here, we will discuss key experimental evidence that support how different internalization routes, the generation of diverse endomembrane platforms, and cycles of internalization and recycling ensure polarized compartmentalization of signals, regulating a number of physiological and pathologically‐relevant processes in which the resolution of spatial information is vital for their execution.