Open AccessMolecular profiles of hereditary epithelial ovarian cancers and their implications for the biology of this disease
Author(s) -
Jazaeri Amir A.
Publication year - 2009
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1016/j.molonc.2009.01.001
Subject(s) - ovarian cancer , germline , context (archaeology) , biology , disease , cancer research , brca2 protein , germline mutation , mutation , cancer , genetics , medicine , gene , pathology , paleontology
BRCA1 and BRCA2 germline mutations account for the majority of hereditary ovarian cancers and comprise 10% of total cases. Ovarian cancers arising from these mutations exhibit both overlapping and distinct clinical and molecular features. The expression profiles of sporadic ovarian cancers show similarities to those of BRCA1 and BRCA2‐related tumors suggesting that BRCA‐related pathways may be involved in their development as well. The purpose of this review is to consider the available data on ovarian cancers in the context of other investigations of BRCA‐related transcriptional alterations, and highlight areas for future research.