Open AccessLarge‐scale genomic analysis of ovarian carcinomas
Author(s) -
Gorringe Kylie L.,
Campbell Ian G.
Publication year - 2009
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1016/j.molonc.2008.12.005
Subject(s) - biology , genome instability , copy number analysis , comparative genomic hybridization , computational biology , ovarian cancer , breakpoint , disease , genomic dna , cancer , copy number variation , genetics , gene , bioinformatics , cancer research , genome , medicine , dna , chromosome , dna damage
Epithelial ovarian cancers are typified by frequent genomic aberrations that have been difficult to unravel. Recently, high‐resolution array technologies have provided the first glimpse of the remarkable complexity of these aberrations with some ovarian cancers containing hundreds of copy number breakpoints, micro‐deletions and amplifications. Many of these alterations contain cancer‐related genes suggesting that the majority is disease‐associated and not just the product of random genomic instability. Future developments such as next‐generation sequencing and integrated analysis of data from multiple array platforms on large numbers of samples are poised to revolutionise our understanding of this complex disease.