Open AccessThe CALM and CALM/AF10 interactor CATS is a marker for proliferation
Author(s) -
Archangelo Leticia Fröhlich,
Greif Philipp A.,
Hölzel Michael,
Harasim Thomas,
Kremmer Elisabeth,
Przemeck Gerhard K.H.,
Eick Dirk,
Deshpande Aniruddha Jayant,
Buske Christian,
Hrabé de Angelis Martin,
Olalla Saad Sara Teresinha,
Bohlander Stefan K.
Publication year - 2008
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1016/j.molonc.2008.08.001
Subject(s) - cats , biology , haematopoiesis , microbiology and biotechnology , cell culture , cancer research , stem cell , genetics , medicine
The CATS protein was recently identified as a novel CALM interacting protein. CATS increases the nuclear and specifically the nucleolar localization of the leukemogenic CALM/AF10 fusion protein. We cloned and characterized the murine Cats gene. Detailed analysis of murine Cats expression during mouse embryogenesis showed an association with rapidly proliferating tissues. Interestingly, the Cats transcript is highly expressed in murine hematopoietic cells transformed by CALM/AF10. The CATS protein is highly expressed in leukemia, lymphoma and tumor cell lines but not in non‐proliferating T‐cells or human peripheral blood lymphocytes. CATS protein levels are cell cycle dependent and it is induced by mitogens, suggesting a role of CATS in the control of cell proliferation and possibly CALM/AF10‐mediated leukemogenesis.