Elevated levels of epithelial neutrophil activating peptide-78 (ENA-78) (CXCL5) and Interleukin-1β is correlated with varicocele-caused infertility: A novel finding | Zendy

Alireza Nazari | Zendy; Gholamhossein Hassanshahi | Zendy; Hossein Khorramdelazad | Zendy

Open Access

Elevated levels of epithelial neutrophil activating peptide-78 (ENA-78) (CXCL5) and Interleukin-1β is correlated with varicocele-caused infertility: A novel finding

Author(s) -

Alireza Nazari,

Gholamhossein Hassanshahi,

Hossein Khorramdelazad

Publication year - 2017

Publication title -

middle east fertility society journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 18

eISSN - 2090-3251

pISSN - 1110-5690

DOI - 10.1016/j.mefs.2017.06.002

Subject(s) - varicocele , infertility , unexplained infertility , male infertility , medicine , pathogenesis , andrology , gynecology , pregnancy , biology , genetics

Background: Varicocele is the most common disorder found in subfertile men. Little is known about the potential effects of ENA-78 and IL-1 β on pathogenesis of varicocele and male infertility. Therefore, current investigation was aimed to explore the role of ENA-78 and IL-1 β in varicocele. Methods: To explore association between ENA-78, IL-1 β and infertility, the seminal levels of these mediators were measured in studied groups by ELISA technique. Results: ENA-78 and IL-1β levels were significantly raised in infertile men with varicocele compared to other groups (P < 0.001). Conclusion: Possibly spermatozoa motility of these patients is reduced in response to elevated ENA-78. IL-1 β as the neutrophils products appears to be potential diagnostic biomarkers and therapeutic targets for varicocele-caused infertility

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