Open AccessInterleukin-1β-gene polymorphisms in preeclamptic Egyptian women
Author(s) -
Ahmed Nasr,
Hoda M. El Azizy,
Sahar Hassan,
Hassan Salem,
Nehal Diaa
Publication year - 2017
Publication title -
middle east fertility society journal/middle east fertility society journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.322
H-Index - 18
eISSN - 2090-3251
pISSN - 1110-5690
DOI - 10.1016/j.mefs.2017.05.001
Subject(s) - genotype , preeclampsia , restriction fragment length polymorphism , polymorphism (computer science) , gene , polymerase chain reaction , microbiology and biotechnology , genetics , biology , medicine , pregnancy
Aim of work: To investigate the relationship between IL-1β -31C/T (rs 1143627) and -11T/C (rs 16944) gene polymorphisms and preeclampsia.Patients and methods: Polymorphisms at -31C/T and -511T/C of IL-1β were genotyped using polymerase chain reaction restriction fragment length polymorphisms (PCR-RFLP).Results: Concerning results of interleukin-1β -31C/T, there were no statistically significant differences between the 2 studied groups regarding CC, CT or TT genotypes. Concerning -511T/C gene polymorphisms, there was statistically significant difference between the 2 studied groups regarding TT genotype, but there were no statistically significant differences between the 2 studied groups regarding CC or CT genotypes.Conclusion: To our knowledge, it is the first study to investigate the relationship between IL-1β gene polymorphisms and preeclampsia in Egyptian females