Open AccessLetrozole versus laparoscopic ovarian drilling in infertile women with PCOS resistant to clomiphene citrate
Author(s) -
Mahmoud Ibrahim,
M. Tawfic,
Moamen M. Hassan,
O.H. Sedky
Publication year - 2017
Publication title -
middle east fertility society journal/middle east fertility society journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.322
H-Index - 18
eISSN - 2090-3251
pISSN - 1110-5690
DOI - 10.1016/j.mefs.2017.02.003
Subject(s) - letrozole , polycystic ovary , medicine , ovulation , pregnancy rate , ovulation induction , gynecology , urology , group b , pregnancy , hormone , biology , insulin resistance , insulin , tamoxifen , cancer , breast cancer , genetics
Objective: To compare the efficacy of letrozole and laparoscopic ovarian drilling (LOD) in the induction of ovulation in women with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS).Subjects and methods: A total of 80 women with CC-resistant PCOS were enrolled and randomly allocated into groups A and B. Group A (n = 40) underwent LOD, and group B (n = 40) received 2.5 mg letrozole from days 3 to 7 of menses for up to six cycles. A 6-month follow-up was performed.Results: No statistically significant differences were found in the baseline clinical characteristics and the major serum hormone profiles, women receiving letrozole had a higher rate of ovulation (70 vs. 57.5%) and however, the differences were not statistically significant also there is significant decrease in MAH in group A. The pregnancy rate was 27.5% in group A versus 35% in group B and abortion rate was 18% in group A versus 7% in the other group.Conclusion: Letrozole had superior reproductive outcomes compared with LOD in women with CC-resistant PCOS and seems to be a suitable first-line ovulation induction instead of LOD in those patients