Open AccessEffect of time interval between human chorionic gonadotropin injection and intrauterine insemination on pregnancy rate
Author(s) -
Badeea S. Soliman
Publication year - 2016
Publication title -
middle east fertility society journal/middle east fertility society journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.322
H-Index - 18
eISSN - 2090-3251
pISSN - 1110-5690
DOI - 10.1016/j.mefs.2016.03.001
Subject(s) - medicine , pregnancy rate , gynecology , intrauterine insemination , pregnancy , infertility , obstetrics , artificial insemination , insemination , human chorionic gonadotropin , unexplained infertility , andrology , sperm , biology , hormone , genetics
Background: Controlled ovarian stimulation with intrauterine insemination (COS/IUI) is an established tool in infertility treatment. There has been debate regarding the optimum time at which IUI can be done to yield the peak pregnancy rate.Objective: To compare the effect of postponing IUI 48 h after hCG injection with current practice protocol, on pregnancy rate. Study design: A randomized. controlled study. Setting was at Cytogenetic and Endoscopy Unit, Zagazig University Hospital.Material and methods: This study included one hundred and forty-one infertile couples that had been scheduled for artificial insemination by husband semen. Women were divided into 2 groups: the study group, including seventy women in whom IUI was performed 48 h after hCG injection and the control group, including seventy-one women in whom IUI was done 36 h after hCG injection.Results: The total and clinical pregnancy rate was significantly higher in the study group compared to the control group (25% vs. 10.6% p = 0.03 and 20.31% vs. 7.57% p = 0.03 respectively).Conclusion: This study showed a statistically significant increase in pregnancy rate in women with delaying IUI 48 h after hCG trigger, compared to the pregnancy rate in the women having the standard procedure