Open AccessThe use of clomiphene citrates for ovulation induction in women with functional ovarian cysts
Author(s) -
Mohamed Salaheddin Abdrabbo,
Mohamed Hussein Khalil,
Mervat Elsedeek,
Ahmed Samy El-Agwany
Publication year - 2011
Publication title -
middle east fertility society journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.322
H-Index - 18
eISSN - 2090-3251
pISSN - 1110-5690
DOI - 10.1016/j.mefs.2011.04.003
Subject(s) - ovulation , pregnancy , cyst , ovulation induction , pregnancy rate , medicine , gynecology , ovary , obstetrics , ovarian cyst , hormone , andrology , physiology , biology , surgery , genetics
Objective: To evaluate the effect of clomiphene citrates (CC) on inducing ovulation and on cyst persistence and size in women with functional ovarian cysts.Study design: Randomized controlled trial.Setting: University Maternity Hospital.Subjects: 60 women in 2 equal groups.Methods: Clomiphene citrates treatment, follicle scanning, hormonal assay.Main outcome measures: Ovulation rate, pregnancy rate, cyst persistence, changes in cyst size.Results: CC increased both ovulation and pregnancy rates in women with functional ovarian cysts (56.7% versus 13.3%, p < 0.000 for ovulation and 23.0% versus 6.7%, p < 0.000 for pregnancy). CC also increased cyst persistence rate especially in cases achieving pregnancy (30% versus 6.7%, p < 0.000) but did not increase the size of the cyst, or cause complications in it.Conclusion: Clomiphene citrates significantly increased ovulation, pregnancy and cyst persistence rates in women with functional ovarian cysts
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