Open AccessProgesterone supplementation for prevention of preterm labor: A randomized controlled trial
Author(s) -
Moustafa I. Ibrahim,
Ahmed Ramy,
Moustafa Abdel-Fattah Younis
Publication year - 2010
Publication title -
middle east fertility society journal/middle east fertility society journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.322
H-Index - 18
eISSN - 2090-3251
pISSN - 1110-5690
DOI - 10.1016/j.mefs.2010.03.007
Subject(s) - randomized controlled trial , preterm labor , medicine , obstetrics , gynecology , pregnancy , biology , gestation , genetics
Objective: To evaluate the efficacy of intramuscular progesterone in prevention of preterm labor in high risk cases.Design: Randomized controlled trial.Setting: Ain Shams Maternity hospital.Materials and methods: Singleton pregnant women in their second trimester with a history of previous preterm labor were divided into two groups: progesterone group: received 17-α-hydroxy progesterone caproate (Cidolut depot) one dose of 250mg IM once weekly until 36weeks and placebo group: received standard dose of placebo IM per week. Follow up till delivery.Results: The mean gestational age was 37.4±1.5 in progesterone group vs. 34.7±2.4 in placebo group (P<0.05). In the progesterone group 8 of 25 women delivered before completion of 37 weeks of gestation (32%) and 17 women delivered full term (68%). In placebo group, 13 of 25 women delivered before completion of 37weeks of gestation (52%) and 12 women delivered full term (48%).Conclusion: Our findings support 17-α-hydroxy progesterone as a successful drug in the prevention and decreasing the rate of recurrent preterm labor