A DOUBLE-BLINDED RANDOMIZED CONTROLLED TRIAL ON THE EFFECT OF FLAXSEED AND OLIVE OILS ON CONSTIPATION OF HEMODIALYSIS PATIENTS: PRELIMINARY RESULTS.

Mineral oil has been used in the treatment of constipation in hemodialysis patients. Edible oils could also be a good option for treating this symptom. Therefore we aimed to investigate the effect of flaxseed and olive oils on constipation of hemodialysis patients. This trial was conducted for 4 weeks. Constipation was diagnosed by Rome III criterion. Thirty six constipated patients (18M, 51.0±12.2 years) were randomized into Mineral oil (MG; n=11), Flaxseed oil (FG; n=11) and Olive oil (OG; n=14) groups. The initial dose of each oil was 4 ml/d and was adjusted as needed. There was no difference in total oil used among groups (150.7±43.7 ml, 165.8±53.3 ml, 144.4±49.5 ml, respectively; p=0.61). The prevalence of each Roma III criterion item was similar among the groups.MG (%)OG (%)FG (%)0wk40wk40wk4Abdominal pain54.527.336.49.1*9.10Straining on defecation30.87.734.611.5*34.615.4Lumpy or hard stools32.39.739.712.929.012.9Incomplete evacuation28.118.843.828.128.118.8Anorectal obstruction29.212.545.84.2*25.012.5Manual maneuvers25.0050.00*25.00< 3 evacuation/week36.85.3*31.610.5*31.615.8This preliminary result suggests that olive oil could be a healthy alternative on treatment of constipation in hemodialysis patients.⁎ p<0.05; 0 vs wk4