THE EXPRESSION PROFILING OF INTESTINAL NUTRIENT TRANSPORTER GENES IN RATS WITH RENAL FAILURE | Zendy

Hironori Yamamoto | Zendy; Hiroko Kikuchi | Zendy; Mari Nakao | Zendy; Otoki Nakahashi | Zendy; Sarasa Tanaka | Zendy; Yutaka Taketani | Zendy; Eiji Takeda | Zendy

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THE EXPRESSION PROFILING OF INTESTINAL NUTRIENT TRANSPORTER GENES IN RATS WITH RENAL FAILURE

Author(s) -

Hironori Yamamoto,

Hiroko Kikuchi,

Mari Nakao,

Otoki Nakahashi,

Sarasa Tanaka,

Yutaka Taketani,

Eiji Takeda

Publication year - 2012

Publication title -

kidney research and clinical practice

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.152

H-Index - 20

eISSN - 2211-9140

pISSN - 2211-9132

DOI - 10.1016/j.krcp.2012.04.596

Subject(s) - gene expression , medicine , microarray , transcriptome , microarray analysis techniques , gene expression profiling , transporter , gene , dna microarray , small intestine , endocrinology , bioinformatics , biology , biochemistry

The understanding of intestinal function in chronic kidney disease (CKD) has been important elements in the clinical management of CKD with dietary and drug therapy.Numerous studies have indicated that CKD patients or model rats have enzymatic abnormalities and impairments of absorptive function in the small intestine. However, ithas been still unclear how different of the intestinal function in CKD. In this study, we demonstrated the microarray analysis of global gene expression in intestine of adenine-induced CKD rat. DNA microarray analysis using Affymextrix rat gene chip revealed that CKD caused great changes in gene expression in the rat duodenum: about 400 genes exhibited more than a two-fold change in expression level. Gene ontology analysis showed that a global regulation of genes by CKD involved in iron ion binding, alcoholic, organic acid and lipid metabolism. Furthermore, we found markedly changes of a number of intestinal transporters gene expression related to iron metabolism. These results suggest that CKD may alter some nutrient metabolism in the small intestine by modifying the expression of specific genes. The intestinal transcriptome database of CKD might be useful to develop the novel drugs or functional foods for CKD patients

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