Plasma Brain-Derived Neurotrophic Factor Levels Of Patients Undergoing Hemodialysis And Peritoneal Dialysis | Zendy

Seok Joon Shin | Zendy; Sungjin Chung | Zendy; Hyung Wook Kim | Zendy; Ho Cheol | Zendy

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Plasma Brain-Derived Neurotrophic Factor Levels Of Patients Undergoing Hemodialysis And Peritoneal Dialysis

Author(s) -

Seok Joon Shin,

Sungjin Chung,

Hyung Wook Kim,

Ho Cheol

Publication year - 2012

Publication title -

kidney research and clinical practice

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.152

H-Index - 20

eISSN - 2211-9140

pISSN - 2211-9132

DOI - 10.1016/j.krcp.2012.04.547

Subject(s) - medicine , peritoneal dialysis , hemodialysis , uremia , neurotoxicity , dialysis , endocrinology , inflammation , albumin , plasma levels , brain derived neurotrophic factor , neurotrophic factors , gastroenterology , toxicity , receptor

Recent studies have shown that brain-derived neurotrophic factor (BDNF) is associated with neurotoxic, inflammatory and nutritional status . The pulpose of this study is to investigate the changes in plasma BDNF concentration that were induced by chronic uremic condition. Using an enzyme-linked immunosorbent assay (ELISA), we measured peripheral BDNF levels in pre-hemodialysis (pre-HD), peritoneal dialysis (PD) patients and in a control group. The plasma BDNF concentrations of pre-HD, PD patients were significantly higher compared with those of controls (856.3 ± 879.1, 1167.9 ± 647.5 versus 403.1 ± 288.9 pg/ml, respectively). The plasma BDNF in dialysis patients was positively correlated with high-sensitivity C reactive protein (hs-CRP) and with serum albumin negatively.Plasma BDNFhs-CRPAlbuminrprpPre-HD0.3210.025-0.2980.021PD0.4140.070-0.5270.008Pre-HD + PD0.4460.001-0.4530.001In conclusion, BDNF might plays some role in the neurotoxicity of uremia and associated with inflammation and malnutrition in dialysis patients

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