Open AccessASSOCIATION OF SERUM ALBUMIN AND MORTALITY IN ELDERLY DIALYSIS PATIENTS
Author(s) -
Alla Victoroff,
Miklos Z. Molnar,
Jennie Jing,
Elani Streja,
Vanessa Ravel,
Debbie Benner,
Csaba P. Kövesdy,
Joel D. Kopple,
Kamyar KalantarZadeh
Publication year - 2012
Publication title -
kidney research and clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.152
H-Index - 20
eISSN - 2211-9140
pISSN - 2211-9132
DOI - 10.1016/j.krcp.2012.04.422
Subject(s) - albumin , dialysis , hemodialysis , medicine , serum albumin , proportional hazards model , hazard ratio , comorbidity , gastroenterology , malnutrition , confidence interval
Low serum albumin level is the strongest mortality-predictor in maintenance hemodialysis (MHD) patients. It is not known whether this association is consistent across all age groups, especially in the elderly. We examined the association of serum albumin and all–cause mortality in 105,523 MHD patients across different age groups using Cox models to estimate death hazard ratios for quarterly averaged serum albumin increments controlled for case–mix, comorbidity, dialysis dose, and available markers of malnutrition–inflammation–complex syndrome (MICS) in all age groups. In those <65 yr, higher alb>4.0g/dL continues to provide incremental survival advantage (Panel A), whereas in patients >65 yr old, no additional survival gain is observed beyond 4.0−g/dL (Panels B-D).High albumin levels are linearly associated with greater survival in all MHD patients although in the elderly gain stops at albumin >4.0 g/dL
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