Open AccessDIFFERENT ACUTE METABOLISM OF FRUCTOSE IN DIALYSIS PATIENTS COMPARED TO HEALTHY SUBJECTS
Author(s) -
Björn Anderstam,
Ann-Christin Bragfors-Helin,
Jonas Axelsson,
Abdul Rashid Qureshi,
Rolf Wibom,
Bengt Lindholm,
Peter Stenvinkel
Publication year - 2012
Publication title -
kidney research and clinical practice
Language(s) - English
Resource type - Journals
eISSN - 2211-9140
pISSN - 2211-9132
DOI - 10.1016/j.krcp.2012.04.328
Subject(s) - fructose , medicine , sucrose , uric acid , high fructose corn syrup , corn syrup , endocrinology , meal , diabetes mellitus , metabolism , food science , chemistry
The consumption of fructose has increased dramatically during the last two decades and parallels the epidemics of obesity, metabolic syndrome, diabetes and chronic kidney disease ADDIN EN.CITE ADDIN EN.CITE.DATA . Fructose comes naturally e.g. in fruit and in honey, both sole as monosaccharide and as sucrose. High-fructose corn syrup is an American substitute for sucrose containing 55% fructose.6 HD-patients and 9 healthy subjects consumed 190 ml cream and 75 g sucrose. Fructose and uric acid were analyzed postprandially during 240 min. For this study we used a new sensitive fructose assay.Fat/carbohydrate loading resulted in different acute fructose responses (see figure) and whereas uric acid levels remained stable in controls, it increased by 10 % in HD patients.fx1We conclude that a fatty meal is associated with a delayed post-prandial fructose absorption and/or metabolism, as well as increased uric acid levels in HD patients. In an ongoing new study, the fructose metabolism will be further studied in CKD patients, diabetics and healthy controls