Open AccessVitamin D: And its role in breast cancer
Author(s) -
La PuenteYagüe Miriam,
CuadradoCenzual Maria A.,
CiudadCabañas María J.,
HernándezCabria Marta,
ColladoYurrita Luis
Publication year - 2018
Publication title -
the kaohsiung journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.439
H-Index - 36
eISSN - 2410-8650
pISSN - 1607-551X
DOI - 10.1016/j.kjms.2018.03.004
Subject(s) - medicine , vitamin d and neurology , breast cancer , colorectal cancer , disease , cancer , diabetes mellitus , inflammatory bowel disease , vitamin , vitamin d deficiency , prostate cancer , metastasis , angiogenesis , endocrinology , oncology
Vitamin D is a fat soluble vitamin that plays a role in calcium and phosphorus homeostasis. Recently, extensive research on its extraskeletal actions has linked vitamin D deficiency to an increased risk of infection, diabetes mellitus types 1 and 2, cardiovascular disease, obesity, asthma, inflammatory bowel disease, colon, breast, prostate and ovarian cancer and some neurological diseases. There are various mechanisms by which vitamin D influences the natural history of cancer. These include the role of vitamin D in the induction of apoptosis, stimulation of cell differentiation, anti‐inflammatory and antiproliferative effects and inhibition of angiogenesis, invasion and metastasis. The aim of this review is to clarify the true role of vitamin D in the onset of breast cancer and evolution of the disease after treatment. A further aim is to suggest new research directions to identify indications and requirements for vitamin D supplementation in patients with breast cancer.