Open AccessAssociation of serum nesfatin‐1 concentrations with atrial fibrillation
Author(s) -
Duan XingLiang,
Li Lei,
Li YaNi
Publication year - 2018
Publication title -
the kaohsiung journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.439
H-Index - 36
eISSN - 2410-8650
pISSN - 1607-551X
DOI - 10.1016/j.kjms.2017.12.002
Subject(s) - medicine , atrial fibrillation , adipokine , serum concentration , endocrinology , cardiology , population , logistic regression , gastroenterology , obesity , insulin resistance , environmental health
Nesfatin‐1, a newly discovered adipokine, inhibits inflammatory response. Inflammation is involved in the mechanism of atrial fibrillation (AF). We aim to determine the association between serum nesfatin‐1 concentrations and AF. A population of 200 patients with AF and 108 patients without AF were enrolled in this study. These patients were divided into three subgroups of paroxysmal AF, persistent AF, and permanent AF. Serum nesfatin‐1 concentrations were lower in AF patients than in controls. Logistic regression analysis showed that serum nesfatin‐1 concentrations were inversely associated with AF. Serum nesfatin‐1 concentrations in permanent AF patients decreased compared with those in persistent and paroxysmal AF groups. In addition, persistent AF patients showed reduced serum nesfatin‐1 concentrations compared with paroxysmal AF subjects. Serum nesfatin‐1 concentrations were negatively correlated with left atrial diameter. In conclusion, serum nesfatin‐1 concentrations were inversely correlated with AF development.