Open AccessAssessment of therapeutic effect of human choriogonadotropin in a chemical cystitis model
Author(s) -
Tanik Serhat,
Zengin Kürsad,
Albayrak Sebahattin,
Gurel Abdullah,
Atar Muhittin,
Sahin Sevinc,
Tuzcu Nevin,
Tuzcu Mehmet,
Imamoglu Muhammet Abdurrahim,
Gurdal Mesut
Publication year - 2017
Publication title -
the kaohsiung journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.439
H-Index - 36
eISSN - 2410-8650
pISSN - 1607-551X
DOI - 10.1016/j.kjms.2017.02.003
Subject(s) - medicine , malondialdehyde , interstitial cystitis , glutathione , necrosis , urine , glutathione peroxidase , endocrinology , group a , tumor necrosis factor α , tumor necrosis factor alpha , group b , hormone , andrology , urology , urinary system , oxidative stress , superoxide dismutase , biochemistry , enzyme , chemistry
In this study, female rats induced with chemical cystitis were administered the hormone human choriogonadotropin (HCG), and it was aimed to reveal the usefulness of HCG in the treatment of interstitial cystitis/bladder pain syndrome. The materials for this study were 32 Wistar albino female rats. The study groups were formed as follows: the cystitis group (Group 1), the cystitis + HCG protection group (Group 2), the cystitis + HCG treatment group (Group 3), and the control group (Group 4), with eight rats in each group. In this study, blood and urine samples were taken from the rats, they were euthanized, and their bladders were removed for glutathione, malondialdehyde, tumor necrosis factor alpha, and interferon gamma measurements. It was observed that tissue damage in Group 2 was lower than that in the other two groups. Glutathione levels in Groups 2 and 4 were significantly higher than in Groups 1 and 3 ( p = 0.01). Malondialdehyde levels of Groups 2 and 4 were significantly lower than the values in Groups 1 and 3 ( p < 0.001). When the cystitis groups were compared in terms of their interferon gamma and tumor necrosis factor alpha levels, the lowest interferon gamma and tumor necrosis factor alpha levels were detected in Group 3. It was found that HCG has positive effects on experimental cystitis in rats. This study revealed that HCG should be researched as a therapeutic agent and formed a step for studies to be carried out on this subject.