Open AccessHost and virological characteristics of patients with hepatitis C virus mixed genotype 1 and 2 infection
Author(s) -
Huang ChungFeng,
Huang ChingI,
Yeh MingLun,
Huang JeeFu,
Hsieh MingYen,
Lin ZuYau,
Chen ShinnCherng,
Yu MingLung,
Dai ChiaYen,
Chuang WanLong
Publication year - 2015
Publication title -
the kaohsiung journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.439
H-Index - 36
eISSN - 2410-8650
pISSN - 1607-551X
DOI - 10.1016/j.kjms.2015.02.004
Subject(s) - medicine , hepatitis c virus , genotype , gastroenterology , confidence interval , hepatitis c , hepacivirus , immunology , virus , gene , biology , biochemistry
The prevalence and characteristics of patients with hepatitis C virus mixed genotype 1 and 2 infection (HCV‐1/2) remains unclear. For each HCV‐1/2 patient with histological data available, two age‐ and sex‐matched HCV‐1 and HCV‐2 infected patients were selected for comparison, respectively. Of the 2776 patients, 261 (9.4%) patients were identified as having mixed HCV‐1/2 infection. The histological severity did not differ among HCV‐1/2 patients and controls. The proportion of patients with the interleukin‐28B (IL‐28B) rs8099917 TT genotype did not differ between patients with mixed‐1/2 and HCV‐1 infection (82.6% vs. 86.5%, p = 0.38). However, HCV‐2 infected patients had a significantly higher proportion of the rs8099917 TT genotype compared to patients with mixed HCV‐1/2 infections (91.6% vs. 82.6%, p = 0.03). The HCV RNA levels were similar in patients with HCV‐1/2 and HCV‐1 infections (5.5 ± 0.8 log IU/mL vs. 5.5 ± 0.9 log IU/L, p = 0.73), which were both significantly higher than that of HCV‐2 infection (5.1 ± 0.9 log IU/mL, both p < 0.001). Linear regression analysis revealed that the factors of HCV‐1/2 infection [β: 0.204; 95% confidence interval (CI): 0.183–0.598, p < 0.001], body weight (β: 0.150; CI: 0.003–0.021, p = 0.008), and age (β: −0.139; CI: −0.020 to −0.002, p = 0.01) were independently correlated with HCV RNA levels in patients with HCV‐2 and mixed HCV‐1/2 infection. We concluded that the host genetic and viral presentations of patients with mixed HCV‐1/2 infection were more similar to those of patients with HCV‐1 infection than patients with HCV‐2 infection.