Open AccessEffects of metabolic syndrome, apolipoprotein E, and CYP46 on cognition among Taiwanese Chinese
Author(s) -
Lai ChiouLian,
Liou LiMin,
Liu ChingKuan,
Yang YuanHan,
Lin RueyTay
Publication year - 2014
Publication title -
the kaohsiung journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.439
H-Index - 36
eISSN - 2410-8650
pISSN - 1607-551X
DOI - 10.1016/j.kjms.2014.03.005
Subject(s) - metabolic syndrome , medicine , cognition , apolipoprotein e , allele , mini–mental state examination , effects of sleep deprivation on cognitive performance , cognitive decline , genotype , clinical psychology , psychiatry , cognitive impairment , dementia , genetics , obesity , gene , disease , biology
The combined effects of metabolic syndrome and the apolipoprotein E and CYP46 genotypes on the risk of cognitive decline has yet to be determined among Taiwanese Chinese. Two hundred and nine mentally healthy middle‐aged and older adults were assessed for metabolic syndrome, cognitive function using the Cognitive Abilities Screening Instrument, Mini‐Mental State Examination, ApoE, and CYP46 polymorphisms. There were no differences in cognitive performance, ApoE epsilon4 (ε4) carrier status, or CYP46 genotypes between participants with and those without metabolic syndrome. The ε4 carriers and participants with the AA allele of CYP46 had significantly lower mental manipulation score. Metabolic syndrome and ε4 had synergistic effects on cognitive decline. Therefore, the ε4 carriers and participants with the AA allele of CYP46 have decreased mental manipulation ability. The metabolic syndrome may play a role in subtle cognitive dysfunction in ε4 carriers among Taiwanese Chinese.