Vision improvement in a Taiwanese (Han Chinese) family with Leber's hereditary optic neuropathy | Zendy

Lin HongZin | Zendy; Pang ChengYoong | Zendy; Chen SheePing | Zendy; Tsai RongKung | Zendy

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Vision improvement in a Taiwanese (Han Chinese) family with Leber's hereditary optic neuropathy

Author(s) -

Lin HongZin,

Pang ChengYoong,

Chen SheePing,

Tsai RongKung

Publication year - 2012

Publication title -

the kaohsiung journal of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.439

H-Index - 36

eISSN - 2410-8650

pISSN - 1607-551X

DOI - 10.1016/j.kjms.2012.04.038

Subject(s) - medicine , leber's hereditary optic neuropathy , optic neuropathy , chinese family , family history , brother , mitochondrial dna , han chinese , pediatrics , ophthalmology , genetics , surgery , optic nerve , gene , genotype , sociology , biology , anthropology , single nucleotide polymorphism

In this report, we describe a Taiwanese (Han Chinese) family with Leber's hereditary optic neuropathy. The family carried a mitochondrial DNA mutation ( mtDNA m.14484T>C ) associated with spontaneous visual improvement. A 15‐year‐old boy from this family was diagnosed with Leber's hereditary optic neuropathy 6 months after losing his vision. His vision recovered after 8 months of supportive treatment. His mother, older brother, and two sisters also had the same mutation and had previously experienced vision loss. In this family, there was no male predominance.

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