Open AccessImpact of alfuzosin on sexual function in Taiwanese men with benign prostatic hyperplasia
Author(s) -
Hwang Thomas I.S.,
Chu ShengHsien,
Lin MaoSheng,
Chen ChihShou,
Lee LiangMing,
Chang HongChiang,
Yeh ShauhDer,
Chen WenHsiang,
Chiang PoHui
Publication year - 2012
Publication title -
the kaohsiung journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.439
H-Index - 36
eISSN - 2410-8650
pISSN - 1607-551X
DOI - 10.1016/j.kjms.2012.02.013
Subject(s) - alfuzosin , medicine , international prostate symptom score , lower urinary tract symptoms , erectile dysfunction , sexual function , urology , quality of life (healthcare) , hyperplasia , prostate , nursing , cancer
To assess the effect of alfuzosin (XATRAL) 10 mg once daily on sexual function in men with moderate to severe lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH), patients with suggestive symptomatic BPH, an International Prostate Symptom Score (IPSS) >8 (range of scores, 0–35), and sexual attempts at least once per month were enrolled. All patients received alfuzosin 10 mg once daily for 24 weeks and were asked to complete the IPSS test and Male Sexual Health Questionnaire at weeks 0 (baseline), 1, 4, 12, and 24. Other assessments included the International Index of Erectile Function—five‐item version (range of scores: 5–25), as well as onset of action and peak urinary flow rate ( Q max ). From September 2006 to May 2008, 279 patients were enrolled from nine centers in Taiwan. At 24 weeks, alfuzosin effectively improved LUTS and quality of life, as demonstrated by a reduction in the IPSS total score (17.3 vs. 9.9, p < 0.001) and the IPSS bother score (3.8 vs. 2.5, p < 0.001). The majority (85%) of patients perceived an improvement of urinary symptoms within 1 month of administration. In patients with an International Index of Erectile Function—five‐item version score of ≤16, alfuzosin significantly improved erectile disorder and satisfaction subscores at each time point ( p ≤ 0.02). Prolonged‐release alfuzosin effectively improved LUTS, quality of life, erectile function, and sexual satisfaction in men with BPH and mild to severe erectile dysfunction. Alfuzosin is an effective treatment option for the management of patients with BPH/LUTS and concomitant sexual dysfunction.