Open AccessHigh preoperative ratio of blood urea nitrogen to creatinine increased mortality in gastrointestinal cancer patients who developed postoperative enteric fistulas
Author(s) -
Lin HsingLin,
Chen ChaoWen,
Lu ChienYu,
Sun LiChu,
Shih YingLing,
Chuang JuiFen,
Huang YuHo,
Sheen MawChang,
Wang JawYuan
Publication year - 2012
Publication title -
the kaohsiung journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.439
H-Index - 36
eISSN - 2410-8650
pISSN - 1607-551X
DOI - 10.1016/j.kjms.2012.02.011
Subject(s) - medicine , creatinine , blood urea nitrogen , gastrointestinal cancer , cancer , urea , gastroenterology , surgery , colorectal cancer , chemistry , organic chemistry
Development of an enteric fistula after surgery is a major therapeutic complication. In this study, we retrospectively examined the potential relationship between preoperative laboratory data and patient mortality by collecting patient data from a tertiary medical center. We included patients who developed enteric fistulas after surgery for gastrointestinal (GI) cancer between January 2005 and December 2010. Patient demographics and data on preoperative and pre‐parenteral nutritional statuses were compared between surviving and deceased patients. Logistic regression analysis and receiver operating characteristic (ROC) curves were used to determine the predictors and cut‐off values, respectively. Patients with incomplete data and preoperative heart, lung, kidney, and liver diseases were excluded from the study; thus, out of 65 patients, 43 were enrolled. Logistic regression analysis showed that blood urea nitrogen‐to‐creatinine (BUN/Cr) ratio [ p = 0.007; OR = 0.443, 95% confidence interval (CI), 0.245–0.802] was an independent predictor of mortality in patients who developed enteric fistulas after surgery for GI cancer. In conclusion, the results of our study showed that a high preoperative BUN/Cr ratio increases the risk of mortality in patients who develop enteric fistulas after surgery for GI cancer.