Multiple endocrine neoplasia type 2A | Zendy

Huang ChiungTang | Zendy; Yang WenChi | Zendy; Lin ShengFung | Zendy

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Multiple endocrine neoplasia type 2A

Author(s) -

Huang ChiungTang,

Yang WenChi,

Lin ShengFung

Publication year - 2012

Publication title -

the kaohsiung journal of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.439

H-Index - 36

eISSN - 2410-8650

pISSN - 1607-551X

DOI - 10.1016/j.kjms.2011.11.017

Subject(s) - medicine , pheochromocytoma , multiple endocrine neoplasia , ifosfamide , multiple endocrine neoplasia type 2 , mesna , regimen , medullary cavity , dacarbazine , endocrine system , chemotherapy , oncology , etoposide , hormone , biochemistry , chemistry , germline mutation , mutation , gene

Multiple endocrine neoplasia type 2A (MEN 2A) is an autosomal dominant inherited cancer syndrome that expresses nonendocrine and endocrine tumors. Here, we describe a 42‐year‐old man with an initial presentation of low back pain and hypertension. Clinical assessments revealed pheochromocytoma, medullary thyroid carcinoma with bone metastasis, and parathyroid hyperplasia. MEN 2A was diagnosed, and a family history of pheochromocytoma was traced. Surgical resection of the pheochromocytoma of the adrenal gland resulted in a cure of the patient's hypertension. He received systemic chemotherapy with the “MAID” regimen (mesna, doxorubicin, ifosfamide, and dacarbazine) over three cycles of 3 weeks each, and showed a partial response.

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