Open AccessMultiple endocrine neoplasia type 2A
Author(s) -
Huang ChiungTang,
Yang WenChi,
Lin ShengFung
Publication year - 2012
Publication title -
the kaohsiung journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.439
H-Index - 36
eISSN - 2410-8650
pISSN - 1607-551X
DOI - 10.1016/j.kjms.2011.11.017
Subject(s) - medicine , pheochromocytoma , multiple endocrine neoplasia , ifosfamide , multiple endocrine neoplasia type 2 , mesna , regimen , medullary cavity , dacarbazine , endocrine system , chemotherapy , oncology , etoposide , hormone , biochemistry , chemistry , germline mutation , mutation , gene
Multiple endocrine neoplasia type 2A (MEN 2A) is an autosomal dominant inherited cancer syndrome that expresses nonendocrine and endocrine tumors. Here, we describe a 42‐year‐old man with an initial presentation of low back pain and hypertension. Clinical assessments revealed pheochromocytoma, medullary thyroid carcinoma with bone metastasis, and parathyroid hyperplasia. MEN 2A was diagnosed, and a family history of pheochromocytoma was traced. Surgical resection of the pheochromocytoma of the adrenal gland resulted in a cure of the patient's hypertension. He received systemic chemotherapy with the “MAID” regimen (mesna, doxorubicin, ifosfamide, and dacarbazine) over three cycles of 3 weeks each, and showed a partial response.