Open AccessEvaluation of the biocompatibility of a coating material for an implantable bladder volume sensor
Author(s) -
Kim SuJin,
Lee DongSup,
Kim InGul,
Sohn DongWan,
Park JungYul,
Choi BumKyoo,
Kim SaeWoong
Publication year - 2012
Publication title -
the kaohsiung journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.439
H-Index - 36
eISSN - 2410-8650
pISSN - 1607-551X
DOI - 10.1016/j.kjms.2011.10.016
Subject(s) - biocompatibility , biomedical engineering , medicine , polydimethylsiloxane , coating , biocompatible material , parylene , polyethylene glycol , materials science , nanotechnology , composite material , polymer , chemical engineering , engineering , metallurgy
As the applications for implantable medical devices have increased, the need for biocompatible packaging materials has become important. Recently, we reported an implantable sensor for real‐time monitoring of the changes in bladder volume, which necessitated finding a safe coating material for use in bladder tissue. At present, materials like polyethylene glycol (PEG), polydimethylsiloxane (PDMS) and parylene‐C are used in biomedical devices or as coating materials, owing to their excellent safety in various medical fields. However, few studies have assessed their safety in bladder tissue, therefore, we evaluated the biocompatibility of PEG, PDMS and parylene‐C in the bladder. All three materials turned out to be safe in in vitro tests of live/dead staining and cell viability. In vivo tests with hematoxylin and eosin and immunofluorescence staining with MAC387 showed no persistent inflammation. Therefore, we consider that the three materials are biocompatible in bladder tissue. Despite this safety, however, PEG has biodegradable characteristics and thus is not suitable for use as packaging. We suggest that PDMS and parylene‐C can be used as safe coating materials for the implantable bladder volume sensor reported previously.