Open AccessOverexpression of annexin 1 in the development and differentiation of urothelial carcinoma
Author(s) -
Kang WanYi,
Chen WanTzu,
Huang YaChun,
Su YueChiu,
Chai CheeYin
Publication year - 2012
Publication title -
the kaohsiung journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.439
H-Index - 36
eISSN - 2410-8650
pISSN - 1607-551X
DOI - 10.1016/j.kjms.2011.10.004
Subject(s) - annexin a2 , western blot , immunohistochemistry , medicine , annexin , tissue microarray , annexin a1 , carcinogenesis , urothelium , pathology , cancer research , staining , cancer , biology , gene , urinary bladder , biochemistry
This study investigates the expression of annexin 1 in urothelial carcinoma (UC) and its relation with clinicopathologic factors, and evaluates its potential clinical significance. Annexin 1 expression was analyzed by immunohistochemical staining with manual tissue microarrays and Western blot in UC. Immunohistochemical analysis of UC in tissue microarrays showed that annexin 1 protein was 76.5% (150/196) positive, which was markedly increased compared with that in the normal urothelium 20.8% (5/24) ( p < 0.01). In addition, the positive expression rate of annexin 1 was higher in the high‐grade UC (81.7%; 143/175) than in the low‐grade UC (33.3%; 7/21). Western blot revealed that the expression of annexin 1 was low in low‐grade UC, and markedly increased in high‐grade UC. In conclusion, annexin 1 overexpression is observed in UC, which suggests it may be associated with tumorigenesis and its expression correlates with the differentiation of UC.