An unexpected role of steroid on podocytes: from zebrafish to human nephrotic syndrome? | Zendy

Catherine Meyer-Schwesinger | Zendy

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An unexpected role of steroid on podocytes: from zebrafish to human nephrotic syndrome?

Author(s) -

Catherine Meyer-Schwesinger

Publication year - 2019

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1016/j.kint.2019.01.044

Subject(s) - nephrotic syndrome , zebrafish , context (archaeology) , proteinuria , medicine , kidney , endocrinology , cancer research , biology , genetics , gene , paleontology

In this issue of Kidney International, Jobst-Schwan et al. developed a zebrafish model of MAGI2-deficiency, which recapitulates findings of human nephrotic syndrome due to MAGI2 mutations. The authors use this model system to screen for drugs that might target and alleviate MAGI2-associated nephrotic syndrome pathways. The scientific context of this publication and the significance of its key findings are discussed in this commentary.

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