Don’t trick me twice! | Zendy

Wulf Tonnus | Zendy; Alexia Belavgeni | Zendy; Yanfang Xu | Zendy; Andreas Linkermann | Zendy

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Don’t trick me twice!

Author(s) -

Wulf Tonnus,

Alexia Belavgeni,

Yanfang Xu,

Andreas Linkermann

Publication year - 2019

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1016/j.kint.2018.12.004

Subject(s) - necroptosis , acute kidney injury , kidney disease , medicine , nephrotoxicity , kidney , cisplatin , acute tubular necrosis , renal function , necrosis , nephrology , pathophysiology , cancer , chemotherapy , pathology , pharmacology , biology , apoptosis , programmed cell death , biochemistry

Chemotherapy-induced nephrotoxicity limits the success of cancer therapy. Landau et al. now describe a mechanism by which a first dose of cisplatin renders the kidney sensitive to necroptosis mediated by a second dose. Unresolved injury and sustained necrosis, therefore, may represent a pathophysiological means of transition from acute kidney injury to chronic kidney disease.

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