The (pro)renin receptor: an emerging player in hypertension and metabolic syndrome | Zendy

Nirupama Ramkumar | Zendy; Donald E. Kohan | Zendy

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The (pro)renin receptor: an emerging player in hypertension and metabolic syndrome

Author(s) -

Nirupama Ramkumar,

Donald E. Kohan

Publication year - 2019

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1016/j.kint.2018.10.042

Subject(s) - renin–angiotensin system , wnt signaling pathway , receptor , endocrinology , autophagy , medicine , blood pressure , metabolic syndrome , biology , microbiology and biotechnology , signal transduction , chemistry , biochemistry , obesity , apoptosis

The (pro)renin receptor (PRR) is a multifunctional protein that is expressed in multiple organs. Binding of prorenin/renin to the PRR activates angiotensin II-dependent and angiotensin II-independent pathways. The PRR is also involved in autophagy and Wnt/ß catenin signaling, functions that are not contingent on prorenin binding. Emerging evidence suggests that the PRR plays an important role in blood pressure regulation and glucose and lipid metabolism. Herein, we review PRR function in health and disease, with particular emphasis on hypertension and the metabolic syndrome.

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