Open AccessIgA nephropathy: new insights into the role of complement
Author(s) -
Jürgen Floege,
Mohamed R. Daha
Publication year - 2018
Publication title -
kidney international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.499
H-Index - 276
eISSN - 1523-1755
pISSN - 0085-2538
DOI - 10.1016/j.kint.2018.03.009
Subject(s) - nephropathy , complement (music) , medicine , immunology , biology , endocrinology , genetics , diabetes mellitus , phenotype , complementation , gene
Glomerular complement deposition is common in IgA nephropathy, and recent genome-wide association studies point to a role of complement factor H and complement factor H-related proteins in disease susceptibility. A number of recent studies have now documented elevated levels of some factor H-related proteins in IgA nephropathy, which might contribute to enhanced complement activation.
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