Heterogeneity of renal cortical oxygenation: seeing is believing | Zendy

Roger G. Evans | Zendy; Connie P. C. Ow | Zendy

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Heterogeneity of renal cortical oxygenation: seeing is believing

Author(s) -

Roger G. Evans,

Connie P. C. Ow

Publication year - 2018

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1016/j.kint.2018.01.039

Subject(s) - oxygenation , medicine , cardiology , intensive care medicine

The limited spatial and temporal resolution of available methods for quantifying renal tissue oxygen tension is a major impediment to identification of the roles of renal hypoxia in kidney diseases. Intravital phosphorescence lifetime imaging microscopy allows cellular oxygen tension in the renal cortex of live animals to be resolved to the level of individual tubular cross-sections. This paves the way for future investigations of the spatial relationships between cellular hypoxia and pathophysiological events in kidney disease.

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